在肠-大脑轴内细胞代谢的失调与慢性肠炎的行为变化有关
Jeannie Devereaux1, Ainsley M Robinson1,2,3, Rhian Stavely1,4
1Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia.
Journal of neuroinflammation
|September 27, 2025
概括
在患有慢性肠道炎症的小鼠中,肠-大脑轴代谢失调会改变行为和能量. 这项研究揭示了肠道和大脑的代谢变化如何影响炎症性肠病 (IBD) 症状.
科学领域:
- 神经胃肠病学 神经胃肠病学
- 代谢研究的研究.
- 炎症性肠病 (IBD) 研究研究
背景情况:
- 炎症性肠病 (IBD) 是一种影响生活质量的慢性疾病.
- 肠-大脑轴的干扰与IBD患者的慢性肠炎和心理障碍有关.
- 在IBD中,改变行为和肠-大脑轴代谢途径之间的关系尚未得到充分探索.
研究的目的:
- 在慢性肠道炎症的小鼠模型中调查肠-大脑轴中改变行为和代谢失调之间的联系.
- 探索自发性慢性结肠炎对远端结肠和大脑能量代谢和基因表达的影响.
主要方法:
- 利用代谢表型系统 (间接热量计,呼吸计) 来评估温妮小鼠 (结肠炎) 和C57BL/6 littermates的能量代谢.
- 使用标准测试评估抑郁和焦虑类行为 (明暗,开放场地,高空加迷宫,强迫游泳).
- 通过对结肠和大脑样本的转录组分析,确定关键代谢途径 (糖解,脂肪酸氧化,TCA循环,氧化酸化) 的基因表达.
主要成果:
- 温妮小鼠的能量代谢和自发活动减少,细胞代谢基因表达在远端结肠中发生变化.
- 温妮小鼠的抑郁和焦虑类行为与远距离结肠和大脑的低调代谢基因表达相关.
- 在Winnie小鼠的大脑中观察到高调的亲炎性细胞因子表达.
结论:
- 在肠-大脑轴内细胞代谢的失调是慢性肠道炎症中观察到的行为和能量代谢变化的关键因素.
- 这些发现凸显了肠-大脑轴作为理解和潜在治疗IBD的关键目标.
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