血清维生素C度与生物衰老相反:一个基于人口的横截面研究
Ying Zhang1, Fang Gong2, Ai-Hua Zhang2
1Department of Laboratory Medicine, Obstetrics and Gynecology Hospital of Fudan University, No.419 Fangxie Road, Shanghai, 200011, China.
European journal of medical research
|September 27, 2025
概括
较高的维生素C (Vit C) 水平与较慢的生物衰老有关. 这种关联在老年人和患有慢性病如高血压或糖尿病的人群中更为强烈.
科学领域:
- 生物化学和分子生物学
- 老年学和衰老研究研究.
- 营养科学 营养科学
背景情况:
- 维生素C (Vit C) 具有抗氧化特性,可以减轻氧化应激并影响衰老过程.
- 维生素C状态和生物衰老标志物之间的确切关系仍然不完全理解.
- 现型年龄加速 (PhenoAgeAccel) 作为生物衰老的关键指标.
研究的目的:
- 为了研究血清维生素C (S-vit C) 度与PhenoAgeAccel之间的关联.
- 探索这种关联中潜在的非线性关系和值效应.
- 检查不同的人口和健康子组之间的关联的变化.
主要方法:
- 从NHANES数据对10,118名参与者 (20-79岁) 的横截面分析.
- 权重线性回归和受限立方线分析以建模S-vit C和PhenoAgeAccel的关系.
- 两部分线性回归和日志概率比率测试以确定潜在的值效应,并补充了子组和灵敏度分析.
主要成果:
- 血清维生素C度与PhenoAgeAccel有显著的反向关系.
- 在最高的S-vit C四分位数中,与最低的四分位数相比,S-vit C四分位数中的个体表现出明显较低的PhenoAgeAccel.
- 观察到非线性关联,转折点为1.46 mg/dL;除此之外,较高的S-vit C没有产生进一步的显著益处.
结论:
- 血清维生素C水平与生物衰老相反相关,这表明它可能在健康衰老中发挥作用.
- 这种反向关联在老年人和患有诸如高血压或糖尿病等并发症的人中更为明显.
- 研究结果强调了维生素C状态在调节衰老轨迹方面的重要性,特别是在脆弱人群中.
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