嗅觉丰富对经过骨科手术的老年患者周术时神经认知障碍的影响:多中心随机对照试验的研究方案
Xinchun Mei1,2, Jiayi Wang2,3, Zihan Ni1
1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People's Republic of China.
Trials
|September 27, 2025
概括
这项研究调查了嗅觉丰富作为一种潜在的干预措施,以减少手术后的神经认知障碍在接受手术的老年人. 结果将为预防手术后认知能力下降的新策略提供信息.
科学领域:
- 老年医学 老年医学
- 神经科学是一个神经科学.
- 手术创新 在外科创新.
背景情况:
- 神经认知障碍在老年手术患者中很常见,原因和治疗方法不明.
- 嗅觉障碍与周围手术神经认知障碍 (PND) 有关.
- 在小鼠的嗅觉丰富减少了类似PND的行为,并改善了大脑结构.
研究的目的:
- 确定嗅觉丰富能否减少骨科手术的老年患者的PND.
- 评估一种新型的非侵入性干预措施的疗效,以预防手术后的认知衰退.
主要方法:
- 这是一项虚假控制的,评估者盲目的,随机的试验,招募了686名65岁或以上的接受骨科手术的患者.
- 干预组每天接受两次嗅觉丰富课程;对照组接受假治疗.
- 主要结局:手术后妄想 (3D-CAM) 的发生率;次要结局:通过神经心理测试延迟神经认知恢复和PND.
主要成果:
- 这部分将在研究完成后填写.
结论:
- 这项试验是首次评估老年外科手术患者的PND嗅觉丰富.
- 它解决了PND的基于证据的治疗方法中的一个关键缺口.
- 这些发现可能会导致一种新的治疗方法,用于手术患者的认知保护.
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