一项横截面研究,以确定2型糖尿病患者的身体组成和神经病变之间的关系
María Fernanda Garcés Pérez1,2, Juan Enrique Santos Macías1,2, Arnulfo González Cantú1,2
1Research and Internal Medicine Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo León, México.
糖尿病神经病变与2型糖尿病患者的身体组成有关. 增加脂肪和骨肌指数与外围神经病变有关,但不是自主神经病变.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 糖尿病神经病变是2型糖尿病 (T2DM) 的常见并发症.
- 通过生物阻抗评估的身体组成与糖尿病神经病变之间的关系需要进一步研究.
- 了解这些关联可以为T2DM患者的管理策略提供信息.
研究的目的:
- 调查外围神经病变 (PN) 和自主神经病变 (AN) 与通过生物阻抗测量的身体组成参数之间的关联.
- 分析神经病变与糖尿病持续时间,HbA1c和T2DM患者的脂质概况等因素之间的关系,年龄在18-64岁之间.
主要方法:
- 进行了一项涉及160名T2DM患者的横截面研究.
- 使用密歇根神经病学查仪 (MNSI) 评估了外围神经病症,使用Sudoscan.com评估了自主神经病症.
- 使用生物阻抗 (InBody) 分析身体成分,并使用后勤回归模型进行关联分析.
主要成果:
- 观察到PN (30%) 和AN (35.6%) 的高患病率.
- 患有PN的患者表现出明显更高的内脏脂肪量,手臂脂肪量,干脂肪百分比,手臂周长,手臂肌肉周长和骨肌肉指数 (SMI).
- 后勤回归确定T2DM持续时间,年龄,腿部脂肪质量和SMI作为PN的显著预测因素,但没有发现AN的显著预测因素.
结论:
- 在T2DM患者的身体组成和外围神经病变之间存在显著的关联.
- 增加的脂肪 (内脏,四肢,干) 和较高的骨肌指数与外围神经病变有关.
- 年龄和糖尿病持续时间也与外围神经病变有关,强调了这种并发症的多因素性质.
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