在精神分裂症患者中,BDNF,proBDNF和MMP-9的血度的改变

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Yuhang Liang¹, Hongying Pan¹, Zhilan Yang¹

¹The Mental Hospital Of Yunnan Province, The Affiliated Mental Health Center of Kunming Medical University, Yunnan Kunming, 650224, China.

European journal of medical research

|September 27, 2025

概括

精神分裂症患者表现出大脑衍生神经营养因子 (BDNF) 和矩阵金属蛋白酶-9 (MMP-9) 的水平发生变化. 这些生物标志物与临床症状和脂质代谢相关,表明它们在精神分裂症诊断中的潜在作用.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
生物化学生物化学

背景情况:

精神分裂症 (SCZ) 是一种复杂的精神疾病,与中断的神经营养因子信号传递有关.
大脑衍生神经营养因子 (BDNF) 和它相关的蛋白质在神经元功能和可塑性中起着至关重要的作用.

研究的目的:

在SCZ患者中调查BDNF,proBDNF和矩阵金属蛋白酶-9 (MMP-9) 的血水平.
探索这些生物标志物,临床症状和SCZ中的脂质代谢之间的关系.

主要方法:

分析了来自105名SCZ患者和76名健康对照者的血样本.
神经心理学评估包括中文版本的神经心理状态评估重复电池 (CRDPSS) 和正负综合征量表 (PANSS).
测量了生物标志物水平 (BDNF,proBDNF,MMP-9) 和脂质配置文件.

主要成果:

与HC相比,SCZ患者的BDNF水平显著降低,proBDNF和MMP-9水平较高.
MMP-9水平与负症状得分 (CRDPSS,PANSS) 和总PANSS得分负相关.
BDNF与总胆固醇 (TC) 有正相关,而MMP-9与TC有负相关.
一个基于MMP-9的模型在区分SCZ患者和HC患者方面表现出高精度 (AUC0.944-0.961).

结论:

改变的BDNF和MMP-9水平与SCZ的病理生理学有关.
MMP-9和BDNF显示出作为精神分裂症诊断生物标志物的潜力.
BDNF/proBDNF和改变的MMP-9的不平衡可能导致SCZ的临床特征,包括负面症状和脂质代谢障碍.

关键词:

这就是为什么BDNF是BDNF.诊断生物标志物诊断生物标志物脂质代谢脂质代谢是一种在MMP-9中,它是MMP-9的.这就是ProBDNF.精神分裂症是一种精神分裂症.

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