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Updated: Jan 16, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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由铁催化 [2 + 2] - 循环添加启动的和脚手架的基础上合成含有循环布坦的三环β-乳酸盐

Lea Freitag1,2, Johannes Zeh1, Levi A Ziegenhagen1

  • 1Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.

Chemistry (Weinheim an der Bergstrasse, Germany)
|September 27, 2025
PubMed
概括

研究人员开发了一种新方法,利用铁催化剂和光化学合成复杂的三维β-乳酸盐. 这种方法产生了硬的,类似子的结构,对药物化学和药物发现有价值.

关键词:
生物活性化合物 生物活性化合物碳基 C─H 插入这是一个循环加法循环.铁的催化剂是铁的催化剂.在β-lactams中使用.

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