通过T细胞激活疗法诱导的非典型淋巴细胞症在患有血液恶性病的患者中
Tae-Shin Kim1, Hyun Kyung Kim1,2, Seon Young Kim1
1Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
International journal of laboratory hematology
|September 27, 2025
概括
参与T细胞 (TCEs) 可能会导致非典型淋巴细胞 (ALYs) 的暂时增加,这可能表明免疫激活. 在TCE治疗期间监测ALY对于解释结果和潜在预测治疗有效性很重要.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 非典型淋巴细胞 (ALYs) 是具有独特形态的激活淋巴细胞.
- ALYs可以模仿白血病或淋巴瘤细胞,需要在血液恶性瘤中进行分化.
- T细胞参与剂 (TCE) 是一种新型免疫瘤学药物,可能对周围血液样本产生影响.
研究的目的:
- 调查T细胞参与剂 (TCE) 对正在接受治疗的患者非典型淋巴细胞 (ALY) 计数的影响.
- 了解ALYs在对各种TCE疗法的反应中的动态.
主要方法:
- 对全血细胞计 (CBC) 数据和周围血液形态学的回顾性分析.
- 该研究包括28名为多发性骨髓瘤和B细胞淋巴瘤治疗TCEs (cevostamab,linvoseltamab,glofitamab,teclistamab,talquetamab,elranatamab,epcoritamab) 的患者.
主要成果:
- 在28名接受TCE治疗的患者中,在11名患者中观察到异型淋巴细胞 (ALY) 的过渡性增加.
- 这种ALY升高得到了形态学和流细胞计验证,受药物类型,途径和组合治疗的影响.
- 在塞沃斯塔马布治疗后观察到的单细胞和淋巴细胞的暂时减少.
结论:
- ALYs的增加表明TCEs诱导的免疫激活.
- 了解ALY动态对于临床医生和病理学家在TCE治疗期间解释结果至关重要.
- ALY测试可以作为TCE治疗有效性的预测标记.
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