在2型糖尿病患者中,范围内的时间与轻度认知障碍之间的相关性
Jiajun Bao1, Tianhong Xu2, Ting Gu3
1Department of Endocrinology, Rugao People's Hospital, Rugao, Jiangsu, China.
Journal of diabetes investigation
|September 27, 2025
概括
保持最佳时间范围 (TIR) 对于预防患有2型糖尿病 (T2DM) 的老年人轻度认知障碍 (MCI) 至关重要. 较高的TIR水平显著降低了MCI风险,特别是在女性中.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 老年病的医生 老年病的医生
背景情况:
- 2型糖尿病 (T2DM) 在老年人中很普遍.
- 轻度认知障碍 (MCI) 在老年人群中越来越令人担忧.
- 在T2DM中血糖控制和认知功能之间的关系需要进一步阐明.
研究的目的:
- 检查T2DM老年人的时间范围 (TIR) 和轻度认知障碍 (MCI) 之间的关联.
- 确定TIR和其他临床因素对MCI的相对贡献.
- 探索TIR-MCI关系中的性别特异性差异.
主要方法:
- 对203名参与者进行了持续血糖监测 (CGM) 和认知评估.
- 相对权重分析量化了TIR和其他变量对MCI的影响.
- 二元逻辑回归分析了TIR-MCI关联,按年龄和性别分层.
主要成果:
- 时间范围 (TIR) 显示,与MCI的关联比糖尿病持续时间,教育,静脉血压,尿白蛋白-肌素比率和C-更强.
- 增加TIR四分位数与MCI的几率显著降低有关.
- 一个连续的TIR变量显示出与MCI (OR 0.917,P=0.002) 的保护性关联,独立于共变量.
结论:
- 除了血红蛋白A1c,低TIR应该被认为是老年T2DM患者中MCI的危险因素.
- 临床医生应该考虑在这个人群中预防MCI的TIR目标.
- 妇女可以从更高的TIR目标中受益,以减轻MCI风险.
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