益生菌衍生的细胞外囊泡通过肌肉再生减轻肉症
Subin Hwang1, Kun-Ho Seo2, Hyunsook Kim1
1Department of Food & Nutrition, College of Human Ecology, Hanyang University, Seoul, South Korea.
Journal of food science
|September 27, 2025
概括
来自Lentilactobacillus kefiri DH5的后生物细胞外囊泡 (EVs) 能够防止肌肉缩. 这些EV增强肌肉再生和功能,为萨科佩尼亚治疗提供了一种新的后生物治疗策略.
科学领域:
- 微生物学 微生物学
- 细胞生物学 细胞生物学
- 肌肉生理学 肌肉生理学
背景情况:
- 来自乳酸细菌 (LAB) 的后生物细胞外囊泡 (EV) 显示出治疗的前景.
- 这些EVs在缓解肌肉缩中的作用在很大程度上尚未被探索.
研究的目的:
- 研究Lentilactobacillus kefiri DH5 (DH5-EVs) 的后生物EVs对肌肉的保护作用.
- 为了评估棕酸 (PA) 诱导的C2C12细胞肌肉缩中的DH5-EVs和后肢不运动 (HI) 麻症小鼠模型.
主要方法:
- 生物化学和蛋白质组分析特征DH5-EVs.
- 用PA治疗C2C12神经管以诱导缩.
- 在小鼠中,通过后肢不动化 (HI) 诱导了 Sarcopenia.
- 肌肉功能,质量和分子标记被评估为DH5-EV给药后.
主要成果:
- DH5-EVs恢复了肌管完整性,并在PA治疗的细胞中提高了Igf-1的调节.
- 在HI小鼠中,DH5-EV改善了握力和肌肉质量.
- 在HI小鼠中,DH5-EV提高了MyoD,降低了Atrogin-1基因表达,与肌酸相比.
结论:
- 由DH5衍生的EV显示出显著的肌肉保护作用.
- 这些EV增强肌肉再生和功能,表明肌肉健康有前途的后生物策略.
- 这项研究为开发基于EV的肉类症干预措施提供了机制性见解.
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