10天大的新生儿暴露于可卡因和人乳:一个案例报告
Leonardo Corrêa Cardoso1,2, Karol Andriely de Vargas Paier1, Fernanda Ziegler Reginato1,2
1Department of Clinical and Toxicological Analysis, Nucleus Applied to Toxicology, Federal University of Santa Maria, Santa Maria, Brazil.
概括
母乳中的可卡因 (COC) 对婴儿构成风险. 哺乳期COC中毒的早期诊断可以通过激活的部分血栓形成时间 (aTTP) 和免疫染色学检测得到帮助.
科学领域:
- 新生儿健康新生儿健康
- 毒理学 毒理学 毒理学
- 儿科 儿科 儿科
背景情况:
- 世界卫生组织 (WHO) 建议在婴儿出生后的前六个月内仅限于母乳养.
- 母亲吸毒可以通过母乳 (HM) 将物质传递给婴儿.
- 哺乳母亲暴露于可卡因 (COC) 对母乳养婴儿构成潜在的风险.
研究的目的:
- 报告新生儿怀疑乳期可卡因中毒的情况.
- 通过母乳探索潜在的早期生物标志物,以诊断婴儿通过母乳中毒可卡因.
- 强调需要进一步研究可卡因对婴儿健康和凝血参数的影响.
主要方法:
- 一个10天大的婴儿出现了色和.
- 母亲病史显示,她吸入了可卡因化粉.
- 评估了婴儿的临床表现和母亲的药物使用史.
主要成果:
- 婴儿的症状与母亲使用可卡因后的中毒一致.
- 激活的部分血栓形成时间 (aTTP) 可能表明在哺乳期可卡因中毒时肝损伤.
- 免疫染色学试验在紧急情况下为疑似药物暴露提供了快速查.
结论:
- 哺乳期药物中毒,特别是可卡因,是令人担忧的,因为它会在母乳中积累.
- 开发用于早期中毒诊断的新生物标志物对于可卡因等物质至关重要.
- 需要进一步的研究来了解可卡因暴露对婴儿凝血参数的影响.
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