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Updated: Jan 16, 2026

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超微小的化学遗传标签与组转移带

Vedagopuram Sreekanth1, Shaimaa H Sindi1, Santosh K Chaudhary1

  • 1Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.

Angewandte Chemie (International ed. in English)
|September 27, 2025
PubMed
概括

研究人员开发了超小化学遗传标签 (mgTag和cTag) 来研究蛋白质. 这些新的标签是现有的最小的标签,为生物技术和医学带来了新的可能性.

关键词:
这是一个C1域名.化学遗传标签 化学遗传标签诱导的邻近性诱导的邻近性在KRAS信号传输中.分子粘合剂是一种分子粘合剂.

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Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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