第一次与第三方验证的经验:对质子FLASH传递进行强有力的校准和质量保证程序
Chih-Chiang Chang1, Balaji Selvaraj1, Xingyi Zhao1
1New York Proton Center, New York, New York, USA.
Journal of applied clinical medical physics
|September 27, 2025
概括
精确的剂量测量对于质子FLASH放射治疗至关重要. 使用条形电离室阵列 (SICA) 探测器的新校准和质量保证程序可确保高精度的实时剂量和剂量率监测,支持临床实施.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 放射治疗技术 放射治疗技术
背景情况:
- 质子FLASH放射治疗提供了减少正常组织毒性,并由于超高剂量率保持瘤控制.
- 由于极端的剂量率,FLASH的精确剂量测量和质量保证 (QA) 是一个挑战.
- 可靠的校准和质量保证程序对于FLASH治疗的临床进展至关重要.
研究的目的:
- 引入一个有效的常规校准和质量保证程序来进行质子FLASH传递.
- 确保高质量的剂量测量性能,用于临床前和临床应用.
- 为了应对超高剂量速率质子疗法的精确剂量测量方面的挑战.
主要方法:
- 一个带离子化室阵列 (SICA) 探测器在可变和超高剂量速率下与先进的马库斯离子室 (IC) 校准.
- 该SICA探测器用于实时监测质子FLASH输送.
- 第三方成像和辐射瘤核心 (IROC) 热发光剂量计 (TLD) 用于独立验证.
主要成果:
- 校准过程很快,每天QA的时间不到10分钟.
- 该SICA探测器显示出与IC的良好相关性 (R值≈1.00) .
- 由SICA实时监测提供了关键的输送数据,计划和输送的剂量在1%的准确度内通过TLDs进行验证.
结论:
- 使用SICA探测器进行有效的校准和质量保证,可对质子FLASH进行准确的实时剂量和剂量速率监测.
- 开发的程序确保了高精度,由独立的IROC测量验证.
- 这种方法促进了质子FLASH放射治疗的未来临床应用.
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