移植患者的乙型肝炎:澳大利亚单中心对查,疫苗接种和管理的研究
Joanne Peel1, Mei Jie Tang1, Catherine Orla Morrissey1,2
1Department of Infectious Diseases, Alfred Health, Melbourne, Victoria, Australia.
Internal medicine journal
|September 27, 2025
概括
肝炎B (HepB) 查在移植接受者中很高,但疫苗接种完成率低于最佳. 对于这一处于风险的人群,需要改善移植前的 HepB 管理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学 移植医学
- 传染性疾病 传染性疾病
背景情况:
- 关于移植受体的乙型肝炎 (HepB) 查和管理质量的数据有限.
- 移植接受者面临来自供体的HepB感染的风险增加.
研究的目的:
- 在移植前评估HepB查率.
- 为了评估HepB疫苗接种完成率.
- 检查与HepB相关的不良结果的管理,包括爆发或重新激活.
主要方法:
- 400名移植受体 (固体器官和造血干细胞) 的回顾性分析.
- 数据收集于2020年1月至2021年12月的阿尔弗雷德健康,墨尔本.
- 从医疗记录中提取HepB查,疫苗接种和不良事件管理数据.
主要成果:
- 移植前的HepB查率为99.25%.
- 在那些有记录的人群中,HepB疫苗接种课程完成率为59.8%.
- 一个接受者发生了HepB复激活;慢性HepB患病率为0.75%,并得到适当的管理.
结论:
- 虽然HepB查很高,但疫苗接种率低于推值.
- 集中疫苗接种记录可能会提高疫苗接种率.
- 对于这种脆弱群体,需要简化周移植型肝炎管理策略.
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