炎症性关节炎的经济负担:系统性审查
Xiaoyu Zhang1, Jiaru Liu2, Zhengwei Wang1
1King's Health Economics, Institute of Psychiatry, Psychology and Neuroscience at King's College London, The David Goldberg Centre, Box 024, London, SE5 8AF, UK.
PharmacoEconomics
|September 27, 2025
概括
炎症性关节炎对全球经济产生重大影响,药物成本是主要的驱动因素. 未来的研究应该采用全面的成本前景来准确评估经济负担.
科学领域:
- 风湿病学和健康经济学
- 系统审查方法论 系统审查方法论
- 疾病的社会负担
背景情况:
- 炎症性关节炎对医疗保健系统和社会造成重大经济负担.
- 疾病成本 (COI) 研究对于理解和量化这种经济影响至关重要.
- 现有的COI数据需要在不同的全球背景下进行更新和全面分析.
研究的目的:
- 系统地审查和综合目前的炎症性关节炎的疾病成本数据.
- 确定关键的成本驱动因素,并分析成本组件随时间的变化.
- 评估该领域已发表的COI研究的方法质量.
主要方法:
- 在四个主要数据库 (MEDLINE,Embase,Cochrane,HMIC) 进行系统的电子搜索,以查找COI研究.
- 包括在过去二十年内发表的有关炎症性关节炎的研究.
- 将所有成本标准化为2024美元,并使用Larg和Moss和修改后的CHEERS检查清单进行质量评估.
主要成果:
- 包括82项研究,涵盖轴性脊椎关节炎,牛皮关节炎,反应性关节炎和类风湿性关节炎.
- 药物支出是主要的直接医疗保健成本;与疾病相关的生产力损失是主要的间接成本.
- 护理人员的生产力损失很大,但报告不足;药物成本正在增加,而某些亚型的生产力损失和住院费用正在下降.
结论:
- 炎症性关节炎在全球范围内造成了相当大的经济负担,因亚型和地区而异.
- 为了准确评估经济负担,包括全面的成本组件至关重要.
- 对于未来的COI研究,建议对方法进行改进,包括敏感性分析和更广泛的成本前景.
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