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Updated: Jan 16, 2026

Measurements of Physiological Stress Responses in C. Elegans
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Published on: May 21, 2020

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ER应激耐受性是由依赖铜的PERK激酶活性调节的

Sarah E Bond Newton1, Xinglong Shi2, Noah R Beratan2

  • 1Weinberg ALS Center, Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Cell reports
|September 27, 2025
PubMed
概括

胰腺/PKR类内分泌网膜激酶 (PERK) 结合铜,这对其活性至关重要. 调节铜水平会影响细胞ER应激耐受性和体内表型,从而提供新的治疗点.

关键词:
CP: 细胞生物学 细胞生物学压力ERER压力ERER压力这就是ISRR.一个叫Perk的Perk.通过UPR进行全日制检查.铜铜 铜铜的铜.激酶调节 激酶调节压力耐受性 耐压力耐受性

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