弗雷明汉风险评分与发生的癌症和心力衰竭有关
Pieter F van den Berg1,2, Laura I Yousif1, Yvonne Koop2
1Department of Cardiology, Erasmus Medical Centre, Rotterdam, The Netherlands.
European journal of preventive cardiology
|September 27, 2025
概括
弗雷明汉风险评分 (FRS) 预测癌症和心力衰竭 (HF) 的风险更高,建议其使用超出动脉样硬化心血管疾病 (ASCVD) 风险评估. 这一分数在心脏瘤学中是有价值的,用于更广泛的风险分层.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 弗雷明汉风险评分 (FRS) 为动脉样硬化心血管疾病 (ASCVD) 风险分层建立.
- 新出现的证据表明,ASCVD风险因素与癌症和心力衰竭 (HF) 的发生率之间存在联系.
- 癌症和HF的FRS的预测作用需要进一步研究.
研究的目的:
- 调查弗雷明汉风险评分 (FRS) 与发生癌症和心力衰竭 (HF) 的风险之间的关联.
- 探索FRS作为超越ASCVD的风险分层工具的潜力,特别是在心脏瘤学的背景下.
主要方法:
- 对PREVEND研究的后期分析,在英国生物银行得到验证.
- 检查了基线FRS三角动物和发病癌症或HF之间的关联.
- 使用了微灰回归模型,对eGFR和UAC进行调整,将所有原因的死亡率作为竞争风险.
主要成果:
- 在PREVEND (N=8123) 中,最高FRS三位数与最低三位数相比,与癌症 (sHR 2.32) 和HF (sHR 10.08) 的风险显著增加有关.
- 在最高FRS三位数的参与者表现出更糟糕的生存结果.
- 在英国生物库 (N=389942) 的验证证实了这些发现,在最高的FRS三位体中显示出更高的癌症 (sHR 2.05) 和HF (sHR 5.99) 风险.
结论:
- 弗雷明汉风险评分 (FRS) 与新发癌症和心力衰竭 (HF) 的风险有显著关联.
- 这些发现支持FRS在风险分层中的更广泛的临床应用.
- 在心脏瘤学中,FRS可能是一个有价值的工具,用于识别心血管事件和癌症风险增加的个体.
相关概念视频
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
395
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
395
Hazard Ratio
561
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
561
Relative Risk
2.0K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
Heart Failure I: Introduction
707
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
707
Imaging Studies for Cardiovascular System III: X-Ray
466
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
466
Heart Failure IV: Classification and Diagnostic Evaluation
321
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
321


