[手术前双酸盐治疗对帕西甲状腺切除术后一年内原发性甲状腺功能增强症患者的骨矿物密度的影响]
A P Pershina-Miliutina1, A K Eremkina1, I D Ozhimalov2
1I.I. Dedov Endocrinology Research Centre.
Problemy endokrinologii
|September 27, 2025
概括
手术前的双酸盐疗法可能会阻碍原发性甲状腺功能障碍症的副甲状腺切除术后的骨矿物密度恢复. 需要进一步的研究来证实这些发现,并了解双酸盐对术后结果的影响.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 外科手术的结果
背景情况:
- 原发性甲状腺功能障碍症 (PHPT) 通常通过甲状腺切除术 (PTE) 来治疗.
- 双酸盐 (BF) 用于治疗高血症和骨健康,用于高手术风险或延迟手术的患者.
- 手术前BF对PTE后骨组织的影响尚不清楚.
研究的目的:
- 评估手术前双酸盐治疗对PHPT患者甲状腺切除术后一年内骨矿物密度 (BMD) 的影响.
- 使用DXA和3D-DXA来评估BMD和骨微架构.
主要方法:
- 该研究包括50名PHPT患者,分为手术前双酸盐治疗和不治疗的组.
- 使用DXA和3D-DXA与3D-Shaper医疗软件进行骨评估.
- 使用R和Statistica v.13.3.进行了统计分析.
主要成果:
- 基线-代谢是可比的,除了在没有BF的组中比较高的β-交叉落差.
- 两组都通过DXA和3D-DXA通过手术后显示出可比的BMD增加.
- 手术前的BF治疗表明,在特定的股骨区域 (皮层厚度) 中,骨密度恢复的趋势略低.
- 在PTE后的BF组中,在腰椎和部 (DXA) 和大腿骨 (3D-DXA) 中的脊椎骨密度/皮层骨密度中发现了显著的BMD差异.
结论:
- 3D-DXA为PHPT中骨折风险评估提供了宝贵的BMD和微架构学的见解.
- 手术前的双酸盐治疗可能会对PTE后的BMD恢复产生负面影响,特别是在皮质骨.
- 需要进一步的研究来验证这些发现,并阐明双酸盐在术后PHPT管理中的作用.
相关概念视频
01:40Bone Remodeling
40.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.3K
01:17Hormones and Bone Tissue
3.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.7K
01:29Bone Disorders
5.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.1K
00:59The Parathyroid Glands
4.3K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
4.3K
01:21Skeleton and Calcium Homeostasis
5.8K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.8K
01:31Osteoclasts in Bone Remodeling
3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K