在光触发的Fe-Polyphenol聚合物中以酸性生成为驱动的协调转换,用于活性氧物种增强的抗瘤治疗
Ying Wan1,2, Hui Liu1, Lin Gao1
1The Education Ministry Key Lab of Resource Chemistry, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, 200234, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|September 27, 2025
概括
这项研究引入了对光敏感的铁聚协调聚合物 (FeBPs),用于增强瘤治疗. 在小鼠中,FeBPs加速铁的转化,放大反应性氧物种,并实现瘤的完全回归.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 基于铁的芬顿剂显示出由于选择性的瘤治疗的前景.
- 在瘤微环境中低效的Fe3+/Fe2+转化限制了治疗疗效.
- 开发增强铁转化策略对于基于芬顿的有效癌症治疗至关重要.
研究的目的:
- 设计一个对光敏感的Fe-polyphenol协调聚合物 (FeBPs),以提高Fe3+/Fe2+的转化效率.
- 为了研究内部 (光触发的酸化) 和外部 (pH降低) 因素对加速铁转化的协同效应.
- 在黑色素瘤小鼠模型中评估FeBPs的治疗疗效.
主要方法:
- 协调工程策略合成FeBPs集成Fe中心,基于Bodipy的光酸发生器和PEG稳定型多联体.
- 使用630nm辐射触发光诱导酸化并暴露催化站点.
- 评估反应性氧物种 (ROS) 生成,线粒体功能障碍和细胞亡诱导.
- 在体内研究使用黑色素瘤携带的小鼠模型来评估瘤回归.
主要成果:
- FeBPs证明了通过在630nm辐射下通过酸化触媒位点的光触发暴露.
- 由于光引起的内部因素和外部pH值下降,Fe2+再生效率得到了提高.
- ROS流的协同放大导致线粒体功能障碍和亡,实现瘤特异性的恒温干扰.
- 在接受FeBPs治疗的黑色素瘤携带小鼠模型中观察到完整的瘤回归.
结论:
- FeBPs通过利用酸触发的金属-连接体合作关系,为基于铁的疗法建立了一个范例.
- 这种方法克服了基于芬顿的癌症治疗中的pH依赖和低效的Fe3+/Fe2+转换的局限性.
- 这些发现为自适应性金属聚合物热解学提供了基础框架.
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