较高的动脉体增强活性有助于呼吸道适应和脱适应在休息和运动期间到高海拔地区
Ayechew A Getu1,2, L Madden Brewster1, Travis D Gibbons3
1Centre for Heart, Lung and Vascular Health, University of British Columbia - Okanagan Campus, Kelowna, British Columbia, Canada.
The Journal of physiology
|September 27, 2025
概括
高空暴露会增加通风,这是由动脉化学受体活动驱动的. 这种增强的活动有助于适应,即使在返回较低海拔地区后也会持续,在休息和运动期间影响呼吸.
科学领域:
- 生理学 生理学 生理学
- 高度医学 高度医学
- 呼吸系统控制 呼吸系统控制
背景情况:
- 低氧暴露引发了通风的增加,这个过程被称为适应.
- Carotid 化学受体对于动物的呼吸道适应低氧至关重要.
- 缺乏直接评估状动脉化学受体增强活性在适应过程中的作用的人类研究.
研究的目的:
- 评估在高海拔适应和脱适应期间人类的状腺化学受体增强活性.
- 确定带化学受体活动与休息和运动期间的呼吸道适应之间的关系.
主要方法:
- 在海平面,高海拔 (3800米) 和下降后 (1200米) 的14个低地地区,通过高氧通风纳迪尔测量了 carotid chemoreceptor tonic 活性.
- 评估是在休息和运动期间进行的,相对 (50% VO2max) 和绝对强度 (90W) 相匹配.
主要成果:
- 与海平面相比,休息通风在高海拔和下降后显著增加.
- 过氧通气的最低点,指数动脉化学受体活动,在高海拔和下降后在休息和炼期间升高.
- 呼吸道适应程度与心血管化学受体增强活性变化相关 (r2=0.60,P=0.014).
结论:
- 较高的动脉化学受体增强活性与人类高海拔适应有关.
- 这种增强的活动在下降后至少持续3天,在休息和运动期间影响呼吸.
- Carotid 化学受体增强活性在适应和从高海拔地区脱离适应过程中起着重要作用.
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