德国的培养阳性COVID-19相关的肺炎 (CAPA)
Leonie H Aldejohann1, Joerg Steinmann2, Tamara Ruegamer3
1University of Würzburg, Institute for Hygiene and Microbiology, Würzburg, Germany.
International journal of medical microbiology : IJMM
|September 27, 2025
概括
与COVID-19相关的肺阿斯伯吉洛症 (CAPA) 是重症患者的一种严重疾病. 这项研究确定了影响CAPA生存的因素,包括康复性血疗法,并强调了其管理的区域差异.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 与COVID-19相关的肺阿斯伯吉洛症 (CAPA) 是重症COVID-19患者的一种严重并发症.
- 早期诊断和管理CAPA带来了重大的临床挑战.
- 这项研究调查了CAPA在德国医院的高峰季节.
研究的目的:
- 评估培养阳性CAPA的分类方法.
- 评估CAPA发病率,死亡率和风险因素.
- 分析CAPA的临床和实验室管理.
主要方法:
- 对SARS-CoV-2阳性患者,具有Aspergillus阳性呼吸道标本和ARDS的回顾性多中心分析.
- 使用ECMM/ISHAM标准进行分类.
- 统计分析以确定与死亡率相关的因素.
主要成果:
- 确定了95例培养阳性的CAPA病例,分类为可能的 (36%) 或可能的 (59%).
- 与非ICU相比,ICU中的发生率更高.
- 病例死亡率为60%,其中Aspergillus fumigatus是最常见的物种 (93%).
- 转基因指数>3和尼古丁滥用与死亡率有关,而康复性血治疗与死亡率降低有显著关联.
结论:
- 在德国,CAPA患病率,诊断和治疗存在区域差异.
- 确定了影响CAPA患者生存率和死亡率的新因素.
- 康复性血治疗可能会降低CAPA患者的死亡率.
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