复发性复发性多发性硬化症高效治疗策略的演变:现实生活观察研究
Judicaelle Didierjean1, Laurent Kremer1, Livia Lanotte1
1Hôpital de Hautepierre, 1 avenue de Molière 67200 Strasbourg, France.
Multiple sclerosis and related disorders
|September 27, 2025
概括
神经科医生现在对复发性复发性多发性硬化症 (RRMS) 处方疾病修饰性治疗 (DMT) 更快,在2007年至2022年期间观察到高效疗法 (HET) 的显著增加.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 临床治疗学 临床治疗学
背景情况:
- 多发性硬化症 (MS) 治疗环境已经发生了显著的变化.
- 诊断标准和治疗建议的变化会影响临床实践.
- 专注于疾病修饰治疗 (DMT) 治疗复发性复发性多发性硬化症 (RRMS).
研究的目的:
- 分析RRMS中DMT处方的演变.
- 从2007年到2022年,追踪神经科医生处方实践中的变化.
- 评估采用高效疗法 (HETs) 的情况.
主要方法:
- 法国阿尔萨斯地区的多中心,描述性回顾性研究.法国.
- 包括1155名RRMS患者在2007年至2022年期间处方DMT.
- 定义的HETs是fingolimod,cladribine,rituximab,ocrelizumab,ofatumumab,和natalizumab. 这三种药物被认为是HETs.
主要成果:
- 显著缩短了第一次DMT处方的时间 (从~1年到<4个月).
- 近年 (2018-2022) 规定的HET比例增加.
- 患者个人资料的转变引发了HETs,特别是在专业中心/医院.
结论:
- 在RRMS中,神经科医生对初始DMT处方的决策已经发生了很大变化.
- 有证据表明,治疗启动速度加快,先进疗法使用量增加.
- 在专业中心/医院和私人诊所之间注意到实践差异.
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