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预产期婴儿和新生儿呼吸衰竭中的产前皮质类固醇暴露:基于人口的队列研究
Yuanyuan Chen1, Xinghe Bu1, Jianguo Zhou1
1Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, National Health Commission (NHC) Key Laboratory of Neonatal Diseases, 399 Wanyuan Rd, Shanghai 201102, China.
European journal of obstetrics, gynecology, and reproductive biology
|September 27, 2025
概括
预产前皮质类固醇 (ACS) 对期婴儿的暴露与新生儿呼吸衰竭 (NRF) 的风险增加有关. 这项研究强调了需要谨慎的ACS管理,以防止新生儿的不良结果.
科学领域:
- 新生儿医学 新生儿医学
- 产科 产科 产科 产科 产科
- 公共卫生 公共卫生
背景情况:
- 产前皮质类固醇 (ACS) 适用于孕妇,以促进胎儿的肺成熟.
- 孕期婴儿暴露于ACS的潜在不良影响越来越令人担忧.
- 了解 ACS 在预产婴儿中的患病率和影响对于优化产科和新生儿护理至关重要.
研究的目的:
- 为了确定产前皮质类固醇 (ACS) 暴露在预产期婴儿中的流行率.
- 在这个人群中识别与ACS暴露相关的风险因素.
- 评估ACS暴露对新生儿呼吸衰竭 (NRF) 发生率的影响.
主要方法:
- 2022年美国国家生命统计系统数据的回顾性队列分析.
- 包括期满的婴儿 (37-41周的孕期).
- 后勤回归和倾向得分匹配 (PSM) 来分析风险因素和NRF关联.
主要成果:
- 在2,883,280名预产婴儿中,有1.2%暴露于ACS.
- 多胎妊娠,较低的妊娠年龄和SGA状态是ACS暴露的重要风险因素.
- 与未暴露的婴儿相比,暴露于ACS的婴儿的NRF风险明显更高 (OR 2.58,p < 0.001).
结论:
- 在很大一部分按期出生的婴儿中观察到ACS暴露.
- 暴露于ACS与新生儿呼吸衰竭的风险增加有关.
- 研究结果表明,需要在终期怀孕中更明智,更有针对性地使用ACS.
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