在不同空间额度下,食omega-3脂肪酸或酵母生物活性物质的层中,Cecal细菌群体和肺免疫
Paul Kibaba Waliaula1, Xinhua Yin2, Dion Lepp2
1Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada; Guelph Research and Development Center, Agriculture and Agri-Food Canada, Guelph ON, Canada.
Poultry science
|September 27, 2025
概括
早期用酵母生物活性 (YB) 或欧米茄-3脂肪酸 (N-3FA) 进行营养,显著影响层状肠道微生物群和免疫反应. 这些饮食干预措施,加上不同间隔的补贴,会长期影响肠道健康和肺部免疫力.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 禽类的肠道微生物群和免疫力受到养环境和饮食的影响.
- 早期营养干预对不同间隔补贴下层肠道健康的长期影响尚不清楚.
研究的目的:
- 为了研究早期饮食酵母生物活性 (YB) 或欧米茄-3脂肪酸 (N-3FA) 对菌群和层的免疫功能的影响.
- 为了评估这些影响,从安置到72周年龄的不同间隔补贴 (SA) 下.
主要方法:
- 在高 (HSA) 或低 (LSA) 间距允许下养育了2,832只Lohmann LSL Lite幼.
- 鸟类从安置到16周的时间被食为对照,N-3FA补充或YB补充的饮食.
- 分析了Cecal样本的细菌数量,16S rRNA测序和短链脂肪酸 (SCFA);肺免疫基因表达也被分析.
主要成果:
- 间隔补贴 (SA) 显著改变了细胞细菌群体结构 (β-多样性) 并增加了LSA中的Bacteroides丰度和propionic/iso-butyric酸.
- 补充N-3FA增加了n-酸盐度,而YB补充与增加的乳酸菌/肠杆菌和n-酸相关.
- 饮食干预和SA调节的肺免疫基因表达,包括IL1β,IL2和IL8.
结论:
- 在不同的SA下,早期服用YB或N-3FA的食补充剂,有效地调节了层的Cecal细菌群落多样性和SCFA概况.
- 这些营养策略增强了肺部的免疫反应,这表明对层次健康的长期益处.
相关概念视频
Development of Human Microbiota
73
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
73
Microbiota of the Large Intestine
110
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
110


