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Updated: Jan 16, 2026

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对中和抗体抑制IL-31信号传递的结构性见解

Tianling Guo1, Yuxin Zheng1, Zheng Fan2

  • 1Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.

Structure (London, England : 1993)
|September 27, 2025
PubMed
概括

研究人员确定了与中和抗体结合的犬类介素-31 (IL-31) 的结构. 这种抗体阻止IL-31与其受体结合,减少狗的炎症和.

关键词:
这是OSMRββ.在STAT5酸化中.晶体结构 晶体结构这是一种单克隆抗体.中和化 中和化 中和化和的情况 和

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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