世卫组织全球冠状球菌抗微生物监测计划,2019-22年:一项回顾性观察性研究
Magnus Unemo1, Monica M Lahra2, Michelle J Cole3
1WHO Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Institute for Global Health, University College London, London, UK.
The Lancet. Microbe
|September 27, 2025
概括
冠状菌抗微生物耐药性 (AMR) 是一个日益增长的全球威胁. 世卫组织的监测显示,对诸如 ceftriaxone 和 azithromycin 等关键抗生素的耐药性日益增加,迫切需要采取公共卫生行动,以保护治疗选择.
科学领域:
- 公共卫生 公共卫生
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 淋病及其抗菌素耐药性 (AMR) 是全球重大健康挑战.
- 加强,质量保证的全球性监测球菌AMR对于为治疗指南和公共卫生战略提供信息至关重要.
研究的目的:
- 报告由世界卫生组织 (WHO) 收集的全球冠状菌AMR监测数据.
- 讨论维持有效淋病治疗能力所需的必要行动.
主要方法:
- 一项回顾性观察性研究分析了77个国家的球菌AMR数据 (2019年1月至2022年12月).
- 测试了关键抗微生物药物的最小抑制度 (塞夫特里亚克松,塞菲西姆,阿齐思罗米,西普罗夫洛克萨).
- 耐药性断点遵循欧洲抗菌感应性测试委员会或临床实验室和标准研究所的指导方针.
主要成果:
- 在全球范围内报告了高耐药率:99%的西普罗夫洛克萨,88%的阿齐思罗米,50%的塞菲西姆,和39%的塞夫.
- 观察到对亚齐菌素,氏和氏的耐药性增加,特别是在世卫组织西太平洋地区.
- 监控在几个地区仍然不足,包括中美洲,加勒比海,东欧,非洲部分地区,东地中海和东南亚.
结论:
- 世卫组织的全球抗菌素耐药性监测正在扩大和改进,随着标准化和质量保证.
- 基于证据的监测数据为管理准则和公共卫生政策提供了信息.
- 预防,诊断,治疗,监测和抗菌药物管理方面的改进对于对抗球菌AMR至关重要.
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