Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Applications of Stress01:04

Applications of Stress

643
Consider a structure made of a boom and a rod designed to support a load. These two components are connected by a pin and stabilized by brackets and pins. The boom and the rod are detached from their supports to assess the different stresses imposed on this structure, and a free-body diagram is drawn. Then, all the forces applied, including the load acting on the structure, are identified. The reaction forces exerted on both the boom and the rod are computed using the equilibrium equations.
The...
643
Stress Concentrations01:24

Stress Concentrations

632
Stress concentration is when stress intensifies near discontinuities such as holes or abrupt cross-sectional changes in a structural member. This localized stress can often surpass the average stress within the member. The stress distribution in flat bars, either with a circular hole or varying widths connected by fillets, can be determined experimentally using a photoelastic method. The results are based on ratios of geometric parameters like the ratio of the hole's radius to the smaller...
632
Stress Concentrations01:13

Stress Concentrations

602
The concept of stress concentration is crucial for understanding how materials respond under bending stresses, particularly when there are irregularities or discontinuities in the material's geometry. Normally, stress in a symmetric member subjected to pure bending is assumed to be uniformly distributed across the entire cross-section. However, this assumption does not hold when there are variations in the cross-sectional geometry or the presence of notches and holes.
The stress...
602
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

576
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
576
Stress: General Loading Conditions01:15

Stress: General Loading Conditions

529
To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes....
529

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A scoping review of the evidence supporting antiarrhythmic use after paediatric cardiac surgery.

Cardiology in the young·2026
Same author

Time-to-Transfer and Hospitalization Duration for Severe Congenital Heart Defects: Implications for Perinatal Regionalization.

The Journal of pediatrics·2026
Same author

Endocardial TIE2 orchestrates cardiac trabeculation via sequestering FOXO1 within the cytoplasm and stimulating versican cleavage.

Development (Cambridge, England)·2026
Same author

Impact of Animal-Assisted Therapy on Quality, Completeness, and Satisfaction in Pediatric Echocardiography.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2026
Same author

Perioperative Metabolomic Profiling in Neonatal Cardiac Surgery Identifies a High-Risk Phenotype for Adverse Outcomes.

JACC. Advances·2026
Same author

Patient-Centered Evaluation of Anticoagulation in Atrial Fibrillation.

NEJM evidence·2026

相关实验视频

Updated: Jan 16, 2026

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

Published on: May 4, 2020

3.9K

贝叶斯对STRESS试验的重新分析

Kevin D Hill1, Jake Koerner2, Hwanhee Hong2

  • 1Duke University Pediatric and Congenital Heart Center, Durham, NC; Duke Clinical Research Institute, Durham, NC.

American heart journal
|September 27, 2025
PubMed
概括

对STRESS试验的贝叶斯分析表明,预防性甲基普雷迪尼索隆显著减少了接受心脏手术的婴儿的不良结果. 这次重新分析表明,受益的概率很高,扩大了最初的发现.

更多相关视频

Enactive Phenomenological Approach to the Trier Social Stress Test: A Mixed Methods Point of View
05:26

Enactive Phenomenological Approach to the Trier Social Stress Test: A Mixed Methods Point of View

Published on: January 7, 2019

7.2K
Using Practice Testing, Public Speaking, and Source Monitoring to Examine the Influences of Learning Strategies and Stress on Episodic Memory
07:59

Using Practice Testing, Public Speaking, and Source Monitoring to Examine the Influences of Learning Strategies and Stress on Episodic Memory

Published on: June 14, 2019

8.3K

相关实验视频

Last Updated: Jan 16, 2026

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

Published on: May 4, 2020

3.9K
Enactive Phenomenological Approach to the Trier Social Stress Test: A Mixed Methods Point of View
05:26

Enactive Phenomenological Approach to the Trier Social Stress Test: A Mixed Methods Point of View

Published on: January 7, 2019

7.2K
Using Practice Testing, Public Speaking, and Source Monitoring to Examine the Influences of Learning Strategies and Stress on Episodic Memory
07:59

Using Practice Testing, Public Speaking, and Source Monitoring to Examine the Influences of Learning Strategies and Stress on Episodic Memory

Published on: June 14, 2019

8.3K

科学领域:

  • 心血管外科心血管外科
  • 儿童心脏病学 儿童心脏病学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 预防性类固醇通常用于减轻婴儿心脏手术期间的全身炎症反应,其中包括心肺旁路.
  • 最初的STRESS试验在甲基前尼索隆和安慰剂之间的结果中没有发现显著差异,尽管二次分析表明了潜在的益处.
  • 用贝叶斯分析重新评估了STRESS试验数据,以更细致地了解甲基prednisolone的影响.

研究的目的:

  • 用贝叶斯方法重新分析STRESS试验数据,以评估甲基prednisolone的益处概率.
  • 调查甲基普雷迪尼索隆在原始STRESS试验的主要终点之外的潜在益处.
  • 探索不同先前信念对甲基普雷迪尼索隆疗效概率的影响.

主要方法:

  • 用一种与共变量调整的比例几率模型与STRESS试验的复合终点 (死亡,移植,重大并发症,停留时间) 进行了调整.
  • 进行了马尔科夫链蒙特卡洛模拟,以确定益处 (OR < 1) 与危害 (OR > 1) 的概率.
  • 灵敏度分析探讨了各种先前的信念 (悲观,中立,乐观) 和先前的优势,以及使用先前类固醇试验的先验结果的二次分析.

主要成果:

  • 甲基普雷迪尼索隆的后期益处概率为92%,危害概率为8%.
  • 甲基普雷尼索隆与复合性死亡或重大并发症的绝对风险差异为-2%有关.
  • 九项敏感性分析始终显示益处的概率高于危害,8项显示>80%的益处概率和≥1%的绝对风险降低.

结论:

  • 贝叶斯式再分析表明,外科手术期间的甲基普雷迪尼索隆在接受心肺旁路术的婴儿中降低了死亡或重大并发症的风险的可能性很高.
  • 这种深入的分析提供了比最初的STRESS试验结果更有力的证据证明甲基前尼索隆的疗效.
  • 这些发现支持在这种患者群体中使用甲基prednisolone作为预防措施.