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在ECHO队列中,在产前暴露于per-和多基物质和早期语言发展之间存在关联
Patricia Cintora1, Lesliam Quirós-Alcalá2, Adaeze W Nzegwu3
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Neurotoxicology
|September 27, 2025
概括
在美国的一项大型研究中,孕前暴露于per-和多醇基物质 (PFAS) 与儿童语言发育无关. 这项研究没有发现PFAS水平与儿童早期的沟通技巧之间存在显著的关联.
科学领域:
- 环境健康 环境健康
- 发育毒理学 发展毒理学
- 儿科神经发育 儿童神经发育
背景情况:
- 产前暴露于per-和多基基物质 (PFAS) 是普遍存在的.
- PFAS对儿童神经发育,特别是语言的影响需要进一步研究.
- 现有的关于PFAS和神经发育的研究已经产生了不确定的结果.
研究的目的:
- 调查产前暴露于特定的per-和多基基物质 (PFAS) 与儿童早期语言发育之间的关联.
- 分析来自多个美国环境影响儿童健康结果 (ECHO) 队列的数据.
- 用标准化工具评估1.5至5岁儿童的语言发展.
主要方法:
- 在怀孕期间量化了四种PFAS的母体血或血清度.
- 使用年龄和阶段问卷,第三版 (ASQ®-3) 和NIH工具箱图片词汇测试 (PVT) 来评估语言发展.
- 使用多变量回归模型和量化g计算来检查单个PFAS,PFAS混合物和语言结果之间的关联.
主要成果:
- 在单个PFAS生物标志物和整体语言发展得分之间没有观察到显著的关联.
- 检查的PFAS混合物没有与ASQ®-3的沟通分数或PVT的词汇分数显著相关.
- 性别分析显示,PFAS暴露与女性的ASQ®-3沟通得分之间存在统计学上显著的负相关性.
结论:
- 对单个PFAS或其混合物的产前暴露与幼儿时期的沟通或词汇成绩没有关联.
- 这些发现表明,常见的产前PFAS暴露可能不会显著影响幼儿语言发展的广泛措施.
- 可能需要进一步的研究来探索PFAS对神经发育轨迹的潜在微妙或性别特异性影响.
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