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含有从HPMCAS-L或PVP-VA喷雾干燥分散的里托纳维尔片的配方优化和比较溶解/透性能

Ayse Nur Oktay1, James E Polli2

  • 1University of Maryland, Department of Pharmaceutical Sciences, Baltimore, MD 21201, USA; University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey.

International journal of pharmaceutics
|September 27, 2025
PubMed
概括

优化无形固体分散 (ASD) 对于平板电脑来说对于溶解不良的药物来说至关重要. 这项研究使用里托纳维尔-HPMCAS-L ASD开发了最佳的片剂配方,实现了有利的溶解和透,突出了配方和工艺参数的重要性.

关键词:
吸收方式 吸收方式解散 解散 解散 是一个过程.优化优化 优化优化透透射是一种透的方法.里托纳维尔 (Ritonavir) 是一种药物.喷雾干燥机 喷雾干燥机药片 药片 药片 药片 是一种药片.

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