夜间高血压和心血管事件:使用倾向性得分匹配风险分析
Joaquin Perea1, Daniel Martin2, Marlon Ruiz Holguín2
1Department of Cardiology, Sanatorio Güemes, Buenos Aires, Argentina; Department of Research, Sanatorio Güemes, Buenos Aires, Argentina.
Current problems in cardiology
|September 27, 2025
概括
夜间高血压 (NHT) 独立增加心血管风险,即使白天血压正常. 夜间静脉压高于148mmHg表示不良事件的临界门.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 临床流行病学临床流行病学
背景情况:
- 夜间高血压 (NHT) 与主要不良心血管事件 (MACE) 和心力衰竭 (HF) 有关.
- 有证据表明,与白天高血压 (DTH) 相比,NHT具有明显的影响.
研究的目的:
- 评估NHT和心血管事件风险之间的独立关系.
- 为了确定NHT是否构成风险,无论白天血压水平如何.
主要方法:
- 使用门诊血压监测数据的观察性研究.
- 倾向性得分匹配 (1:1) 患者组可比性.
- 用于关联分析的考克斯回归和立方线模型.
主要成果:
- 夜间静态血压显著预测MACE/HF (HR 1.04),而不是白天的血压 (HR 0.98).
- 在多变量模型中,NHT独立增加了风险 (HR1.03).
- 观察到一种非线性关联,风险增加超过148 mmHg的夜间缩血压.
结论:
- NHT是心血管事件的独立预测器.
- 对NHT的特定预后值可以提高风险分层.
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