在精神病和情绪障碍中,消极症状和休息状态的功能连接:系统文献综述
Nada Dalloul1, Connor van Huijgevoort1, John Belmont1
1Department of Psychological & Brain Sciences, Washington University, St. Louis, MO, United States.
Neuroscience and biobehavioral reviews
|September 27, 2025
概括
精神病和情绪障碍的负面症状与大脑连接的改变有关. 研究表明特定的静止状态网络变化,但需要更多的研究来开发有效的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算精神病学是一种计算精神病学.
背景情况:
- 负面症状显著导致精神病和情绪障碍的残疾和痛苦.
- 目前针对负面症状的治疗策略受到其潜在神经机制的不完全理解的限制.
- 改变的大脑连接 (失连) 被假设在负面症状的病理生理学中发挥关键作用.
研究的目的:
- 对基于节点的静止状态功能连接和负面症状之间的关系的研究结果进行审查和综合.
- 为了检查这种跨精神病障碍 (精神分裂症,精神分裂情绪障碍) 和具有精神病特征的情绪障碍 (双极性障碍,主要抑郁症) 的关系.
主要方法:
- 一项对40项研究的系统审查,调查休息状态功能连接 (使用网络和图形理论分析) 和负症状.
- 分析的重点是静态网络内部和之间基于节点的连接.
主要成果:
- 有证据表明,精神分裂症和精神分裂情绪障碍的负面症状与几个静止状态网络的连接性发生变化有关,包括侧面前对面,中环岛和体运动网络.
- 研究结果表明,负面症状与功能分离和神经连接集群的减少之间存在潜在联系.
- 关于精神病特征的大型抑郁症和精神病特征双相情感障碍中负面症状和功能连接的研究存在重大差距.
结论:
- 休息状态功能连接性改变与精神疾病的负面症状有关,但由于文献不一致,研究结果需要谨慎解释.
- 未来的研究应该解决负面症状异质性,增强休息状态功能连接方法,并促进标准化网络分析的跨诊断见解.
- 了解这些跨诊断关系对于开发针对性和有效的临床干预来治疗负面症状至关重要.
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