在患有纤维化间歇性肺病的患者经历无意减肥的专家饮食干预:试点随机对照试验
Rasleen Kahai1, Gioele Castelli2, Fiammetta Danzo3
1Interstitial Lung Disease Unit, Royal Brompton Hospital, Guy's & St Thomas' NHS Foundation Trust, London, England; Department of Nutrition and Dietetics, Royal Brompton Hospital, Guy's & St Thomas' NHS Foundation Trust, London, England.
Chest
|September 27, 2025
概括
专家的饮食干预表明,在患有纤维化间歇性肺病 (F-ILD) 的患者中,改善体重是有前途的. 这项试点研究表明,对于这种情况,更大规模的试验是可行的,并且是合理的.
科学领域:
- 肺部医学 肺部医学
- 临床营养学 临床营养学
- 医学研究方法学 医学研究方法学
背景情况:
- 纤维化间歇性肺病 (F-ILD) 患者的体重减轻与预后不佳有关.
- 营养干预对F-ILD结果的影响在很大程度上是未知的.
- 这项研究调查了F-ILD患者减肥饮食干预的可行性.
研究的目的:
- 评估一项随机对照试验 (RCT) 的可行性,用于F-ILD.的专家饮食干预.
- 在饮食干预研究中评估招募,随机化和保留率.
- 探索饮食干预对F-ILD患者体重变化的影响.
主要方法:
- 一个为期12周的随机对照试验,将专家饮食干预与接受饮食信息的对照组进行比较.
- 患有F-ILD和体重低或体重减轻的患者被随机分配为1:1.
- 通过使用抗纤维素药物和随机块设计进行了分层.
主要成果:
- 在7个月内招募40名患者 (31%的查) 表明了试验的可行性.
- 所有随机选择的患者完成了为期12周的研究,证明了高保留率.
- 饮食组的患者显著增加了≥1kg (42%对4.8%),平均体重变化差异为+0.65kg/月,有利于饮食组.
结论:
- 在低体重或体重减轻的F-ILD患者中,专业的饮食干预是可行的.
- 试点试验显示了体重变化的令人鼓舞的结果,支持进一步的研究.
- 确定的多中心随机对照试验是有必要的,以证实这些发现.
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