多基因风险评分和心房发病率之间的性别差异:前性队列研究
Feilong Zhang1, Yuhao Hu1, Jinfeng Wang1
1Department of Cardiology, National Cardiovascular Disease Regional Center for Anhui, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
The Canadian journal of cardiology
|September 27, 2025
概括
性别影响了对心房动 (AF) 的遗传易感性. 具有更高遗传风险的男性和具有更高临床风险的女性面临着更高的AF发病率,突出了针对性别的预防策略的需要.
科学领域:
- 心血管遗传学 心血管遗传学
- 流行病学 流行病学
- 疾病中的性别差异.
背景情况:
- 在心房动 (AF) 的流行病学和结果中确立了性别差异.
- 性别在调节发生性AF的遗传易感性中的作用尚不清楚.
研究的目的:
- 评估多基因风险评分 (PRS) 对AF发病率的性别特异性影响.
- 通过临床风险分数分层评估性别特异性的PRS影响.
主要方法:
- 对4444463名没有肌痛性肌痛的英国生物库参与者的前性队列研究.
- 按性别分层,AF-PRS,以及心脏和衰老研究中的基因组流行病学对心房的临床风险评分 (CHARGE-AF) 的队列.
- 考克斯风险回归分析了AF-PRS,性别和CHARGE-AF之间的相互作用.
主要成果:
- 在发生的AF上,男性性别和更高的AF-PRS之间存在显著的相互作用 (HR 0.95,P=0.031).
- 女性在CHARGE-AF得分较高时表现出更高的遗传敏感性;男性在CHARGE-AF得分较低时表现出更高的敏感性.
- 一个显著的三方相互作用 (AF-PRS × 性别 × CHARGE-AF,HR 0.84,P<0.001) 验证了性别特定的发现.
结论:
- AF-PRS和事件AF之间的关联因性别而有所改变.
- 临床风险负担影响性相关的PRS对AF的影响.
- 对AF遗传易感性的性别和上下文依赖的方法对于精确的预防至关重要.
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