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Updated: Jan 16, 2026

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氧化功能化的可电离脂在mRNA疗法中减轻炎症反应

Kepan Chen1, Xuechun Li1, Shuo Feng1

  • 1State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China; Center for mRNA Translational Research, Fudan University, Shanghai 200438, China.

Journal of controlled release : official journal of the Controlled Release Society
|September 27, 2025
PubMed
概括

新型抗炎性电离性脂质与氧化 (HCQ) 功能化降低了脂质纳米粒子 (LNP) 中的免疫激活. 这些HCQ功能化的LNP (HL LNP) 能够实现更安全的mRNA疗法,减少炎症和持续作用.

关键词:
氧化chloroquine 的使用情况.炎症性副作用 炎症性副作用脂质纳米颗粒的使用方法这是mRNA疫苗.

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