病毒物种对生命早期下呼吸道疾病的独立和相互作用作用
Camille M Moore1, Elizabeth A Secor2, Ana Fairbanks-Mahnke2
1Center for Genes, Environment & Health, National Jewish Health, 1400 Jackson St, Smith Building, Denver, CO 80206, USA; Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, Mail Stop B119, Aurora, CO 80045, USA.
呼吸道同胞病毒 (RSV) 和其他病毒增加了婴儿严重下呼吸道疾病 (SLRIs) 的风险. 与单一感染相比,病毒共同感染显著提高了患SLRIs的几率.
科学领域:
- 儿童传染病 儿童传染病
- 病毒性呼吸道感染.
- 流行病学 流行病学
背景情况:
- 严重的下呼吸道疾病 (SLRIs) 是婴儿发病的主要原因.
- 识别与sLRIs相关的特定病毒病原体对于预防和治疗策略至关重要.
研究的目的:
- 调查不同病毒物种之间的关联以及在两岁以下的儿童中发展严重下呼吸道疾病 (SLRIs) 与上呼吸道疾病 (URIs) 的可能性.
主要方法:
- 在波多黎各,一组2061名婴儿被监测到呼吸系统疾病,直到2岁.
- 来自1363种疾病的鼻子抽样被分析为21种常见的呼吸道病原体.
主要成果:
- 呼吸道同胞体病毒 (RSV) 感染与显著更高的sLRIs几率有关 (OR=9.28).
- 甲肺病毒,偏流感和非SARS-CoV-2冠状病毒也增加了sLRI风险,而SARS-CoV-2显示出一种保护性关联.
- 病毒的同时感染,特别是与犀牛病毒和口腔病毒的同时感染,大大增加了sLRIs的几率 (OR=2.92).
结论:
- 各种病毒病原体有助于生命早期的SLRIs.
- 一些像RSV这样的病毒本质上会导致sLRIs,而其他病毒的致病性则受到共感染等因素的影响.
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