毒素菌改变了猫的肠道微生物群和系统代谢:一种多omics方法
Ji-Xin Zhao1, Xue-Yao Wang2, Xuancheng Zhang3
1College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, PR China; College of Life Sciences, Changchun Sci-Tech University, Shuangyang 130600, PR China.
Veterinary journal (London, England : 1997)
|September 27, 2025
概括
毒素菌感染显著改变猫的肠道微生物群和宿主代谢. 这项研究揭示了寄生虫诱导的微生物功能和系统代谢途径的转变,影响宿主-寄生虫相互作用.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 微生物组研究 微生物组研究
- 主体-寄生虫的相互作用
背景情况:
- 毒素菌 (T. gondii) 是一种有义务的细胞内寄生虫,其最终宿主是猫.
- T. gondii对猫肠道微生物群和系统代谢的影响基本上是未知的.
- 了解这些相互作用对于猫的健康和毒素菌管理至关重要.
研究的目的:
- 研究T. gondii感染对猫肠道微生物群和宿主的全身新陈代谢的影响.
- 为了阐明宿主-寄生虫-微生物群在猫的T. gondii感染期间的相互作用.
- 为了确定与T. gondii感染相关的特定微生物和代谢变化.
主要方法:
- 多omics方法结合了便样本的元基因组测序和非目标血清代谢学.
- 对肠道微生物多样性,组成和功能基因配置文件的分析.
- 液体染色学-并联质谱学 (LC-MS/MS) 用于血清代谢物分析.
主要成果:
- 淋巴菌感染显著破坏了肠道微生物的多样性,组成和功能,特别是在性复制期间.
- 对参与维生素,辅助因子和能量代谢的微生物基因进行下调;对碳水化合物代谢途径进行上调.
- 主体脂质特征,氨基酸通路和叶酸代谢的明显变化,与特定微生物和主体代谢物之间的相关性.
结论:
- 淋巴菌感染严重改变了猫的肠道微生物功能和全身代谢.
- 特定的微生物种群与宿主对感染的代谢反应密切相关.
- 这些发现为宿主-寄生虫-微生物群动态和毒素菌的潜在治疗点提供了新的见解.
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