环境抗体和抗菌素耐药性:整合一个健康的框架
Kainat Raziq1, Ramish Saleem2, Saba Zafar3
1Department of Zoology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, 63100, Pakistan. KainatRaziq123@gmail.com.
Naunyn-Schmiedeberg's archives of pharmacology
|September 27, 2025
概括
抗菌素耐药性 (AMR) 是人类,动物和环境系统所放大的一种全球性威胁. 承认环境微生物群是抗菌素耐药性基因 (ARG) 的关键储存库和传播途径,对于有效的"一健康"战略至关重要.
科学领域:
- 环境微生物学环境微生物学
- 一个健康,一个健康.
- 抗微生物耐药性 (AMR) 是一种
背景情况:
- 抗药性耐药性是一个关键的全球健康挑战,由相互连接的人类,动物和环境系统驱动.
- "一个健康"方法整合了这些领域,以全面解决AMR问题.
- 环境微生物群作为抗菌素耐药性基因 (ARG) 的储存库和载体.
研究的目的:
- 审查AMR的环境层面,重点关注微生物组作为ARG储存库和传播载体.
- 突出新兴证据,传播途径,检测方法和政策差距,特别是在低收入和中等收入国家 (LMICs).
- 强调需要整合"一健康"战略和改善环境监测.
主要方法:
- 在环境,临床和分子微生物学研究中进行了深入的文献综合.
- 对抗力和ARG传输路径的生态进化动态的分析.
- 评估当前的监控模型和新型检测技术.
主要成果:
- 土壤,水,空气和废物中的环境抗体通过横向基因转移和移动遗传元素显著促进ARG传播.
- 像重金属和生物制剂这样的共同选择剂促进了ARG在复杂微生物群落中的持久性和进化.
- 当前的监测系统往往忽视了环境因素,特别是在LMICs,阻碍了AMR缓解.
结论:
- 环境微生物组是抗药性反应的核心,需要在全球控制工作中得到认可.
- 综合"一个健康"战略,加强环境监测,政策改革和技术干预对抗药物耐药性控制至关重要.
- 弥合研究政策差距和加强地方监测对于改善耐药性管理和公共卫生至关重要.
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