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Updated: Jan 16, 2026

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由AMPK激活的BAP1调节了pVHL稳定性和瘤抑制功能

Mei Li1,2, Lei Huang2, Jiayi Chen2

  • 1Department of Clinical Pharmacy, Central People's Hospital of Zhanjiang, Zhanjiang, China.

Cell death and differentiation
|September 27, 2025
PubMed
概括

失调的葡萄糖代谢破坏了瘤抑制剂希佩尔-林道 (VHL) 蛋白的稳定. 能量压力激活AMPK,后者酸化BAP1,稳定VHL及其在癌症中的瘤抑制功能.

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