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rTMS通过协同的大脑网络重组和外围生物标志物动态来调节早期的AD进展

Tian Wang^1,2,3,4, Miaomiao Guo^5,6,7,8, Hao Wu^9,10

¹School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300130, China.

|September 27, 2025

概括

在阿尔茨海默氏病 (AD) 患者中,重复性横磁刺激 (rTMS) 改善了认知和减少了症状. 治疗提高了大脑网络的效率,调节了Aβ代谢,特别是在早期的AD.

科学领域:

神经科学是一个神经科学.
神经学神经学
生物标志物生物标志物

背景情况:

众所周知,重复性横磁刺激 (rTMS) 在阿尔茨海默氏症 (AD) 中可以改善认知能力.
然而,它对阿尔茨海默氏症生物标志物和神经可塑性的影响仍然不完全理解.
了解这些机制对于优化rTMS作为治疗策略至关重要.

研究的目的:

研究14天,20赫兹rTMS干预对阿兹海默症患者认知功能,血生物标志物和大脑网络特征的影响.
探索生物标志物变化,神经可塑性和rTMS后的认知改善之间的关系.
为了确定在AD中对rTMS的反应的潜在预测因素.

主要方法:

对AD患者进行了为期14天的20HzrTMS干预.
用MMSE,MoCA和RAVLT等级来评估认知表现.
测量了等离子体生物标志物,包括神经丝光链和Aβ物种.
休息状态功能磁共振成像 (fMRI) 用于分析大脑网络属性,如全球效率和连接密度.

主要成果:

rTMS显著改善了认知评分 (MMSE,MoCA,RAVLT) 并减少了神经精神疾病症状 (NPI,HAMD).
观察到神经纤维光链水平减少9.4%,基线p-Tau181与Aβ42变化相反相关.
确定了神经网络中增强的全球效率和连接密度,与Aβ42/40和认知收益 (MoCA) 有积极的相关性.

结论:

rTMS通过增强大脑网络的整合和调节Aβ代谢,显示出缓解AD神经退行症的潜力.
观察到的益处在早期阿兹海默症患者中更明显,神经完整性得到保护.
这些发现有助于理解TMS神经调节机制,并推进AD的治疗评估框架.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.生物标志物生物标志物临床评估临床评估功能连接性的功能连接性.功能性磁共振成像技术功能性磁共振成像技术通过骨磁刺激进行磁性刺激.

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