糖尿病是心脏移植后越来越常见的问题:综合糖尿病护理的案例
Lisa M Raven1, Andrew Jabbour2, Peter S Macdonald2
1Department of Diabetes and Endocrinology, St Vincent's Hospital, Sydney, NSW, Australia; Clinical Diabetes, Appetite and Metabolism Laboratory, Garvan Institute of Medical Research, Sydney, NSW, Australia; School of Clinical Medicine, St Vincent's Campus, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.
Heart, lung & circulation
|September 27, 2025
概括
糖尿病发生率和患病率在20年内在心脏移植接受者中显著增加. 这凸显了综合性内分泌治疗的必要性,以改善移植后的管理.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 移植医学 移植医学
背景情况:
- 正位心脏移植 (OHT) 存活率因免疫抑制技术的进步而有所改善.
- 糖尿病,无论是先前存在的 (T2DM) 或移植后 (PTDM),是OHT接受者的常见并发症.
- 增加对移植后护理的关注,需要了解OHT患者的糖尿病趋势.
研究的目的:
- 为了比较OHT接受者的糖尿病发病率和患病率,跨越两个不同的20年队列.
- 分析二十年来移植前2型糖尿病 (T2DM) 和移植后糖尿病 (PTDM) 的变化.
主要方法:
- 进行了回顾性审计,比较了1996-1998年和2015-2018年的OHT受益人.
- 该研究分析了T2DM的患病率和PTDM的累积两年发病率.
- 研究人员检查了早期队列中的88名接收者和后期队列中的141名接收者的数据.
主要成果:
- 在1998年至2018年期间,移植前T2DM的患病率从6%增加了三倍至18% (p=0.009).
- 在同一时期,PTDM的发病率从16%上升到36% (p=0.001).
- 开发PTDM的OHT接受者在后期队列中年龄较大 (平均年龄为52岁与44岁;p=0.03).
结论:
- 在过去的20年里,糖尿病的发病率和患病率在OHT接受者中显著增加.
- 在OHT后糖尿病率的上升强调了内分泌学家参与移植护理团队的必要性.
- 对糖尿病移植患者的降糖疗法进行进一步的研究是有必要的.
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