免疫疗法诱导的肺毒性:全面的放射学审查
Tej Pal1, Chandrashekhara Sh2, Parbhat Singh Malik3
1Department of Radiology, NCI, All India Institute of Medical Sciences, New Delhi, India.
Current problems in diagnostic radiology
|September 27, 2025
概括
免疫检查点抑制剂 (ICI) 可以导致肺毒性,出现在CT扫描上. 本综述指导放射科医生诊断和管理这些ICI诱导的肺部并发症.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
背景情况:
- 免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗.
- 这些疗法可能导致严重的肺毒性,影响2-19%的患者.
- 在CT扫描上的放射图案可以模仿其他肺部疾病.
研究的目的:
- 为放射科医生评估ICI相关的肺部并发症提供一个结构化的方法.
- 综合目前关于放射性图案,诊断挑战和管理的证据.
- 突出早期检测和风险分层方面的进展.
主要方法:
- 对ICI诱导的肺毒性现有文献的综述.
- 在计算机断层扫描 (CT) 图像中分析特征性放射图案.
- 综合诊断途径和治疗策略.
主要成果:
- 常见的CT模式包括组织性肺炎,过敏性肺炎类反应和扩散性气泡膜损伤.
- 将ICI相关的肺损伤与感染,辐射或瘤区分开来是一个关键的挑战.
- 葡萄糖皮质类药物是标准的治疗方法,免疫调节剂正在研究中.
结论:
- 准确诊断ICI相关的肺损伤对于适当的管理至关重要.
- 定量CT分析和生物标志物显示出改善检测和风险评估的前景.
- 一种系统的方法有助于放射科医生管理这些复杂的病例.
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