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神经成像证据表明,在患有发作转化障碍的青少年中,存在结构和网络障碍

Kalpana Dhanik¹, Amit Arya², Vivek Agarwal²

¹Centre of Bio-Medical Research, Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Lucknow, India; Department of Biological Sciences, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.

Epilepsy & behavior : E&B

|September 28, 2025

概括

患有发作的青少年转化障碍 (CD/FS) 显示出不断演变的大脑变化,从局部发展到广泛的结构和网络功能障碍. 早期识别这些特定阶段的变化对于预后和治疗至关重要.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
临床神经学临床神经学

背景情况:

发作性转化障碍 (CD/FS) 是一种复杂的神经疾病,影响青少年.
了解CD/FS的神经生物学基础对于有效管理至关重要.
在CD/FS中,特定阶段的脑部变化需要进一步调查.

研究的目的:

调查CD/FS.青少年的结构和网络级大脑差异.
为了比较CD/FS的急性和持续阶段之间的大脑变化.
探索大脑变化,分离症状和年龄之间的相关性.

主要方法:

60名患有CD/FS的青少年和60名对照的青少年获得了3张特斯拉MRI扫描.
基于voxel的形态学 (VBM) 和基于源的形态学 (SBM) 评估了灰色和白色物质 (GM/WM) 的体积.
连接图分析评估了大脑网络连接,与离散症状相关 (DES分数).

主要成果:

与对照组相比,患有CD/FS的青少年的GM和WM总量减少.
急性阶段的CD/FS显示局部GM增加和WM破坏;持久阶段的CD/FS显示广泛的结构异常.
网络分析显示了渐进的解体,在急性CD/FS中局部破坏,在持久CD/FS中广泛的负连接.

结论:

青少年的CD / FS从局部发展到广泛的结构和网络功能障碍.
早期识别特定阶段的大脑网络变化对于有功能性发作的青少年至关重要.
结果可能会为CD/FS的预后标志物和个性化临床方法提供信息.

关键词:

青少年青少年青少年转化障碍是一种转化障碍.功能性发作功能性发作灰色和白色的物质是什么网络功能障碍网络功能障碍神经成像是一种神经成像.精神引起的非发作.

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