评估荷兰老年人RSV疫苗接种策略的成本效益
Florian Zeevat1, Jos Luttjeboer2, Koos Korsten3
1Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Health-Ecore, Zeist, the Netherlands.
Vaccine
|September 28, 2025
概括
荷兰老年人接种呼吸道同胞细胞病毒 (RSV) 疫苗是具有成本效益的,特别是每三年一次接种一次. 这一策略可以防止住院和死亡,同时降低医疗保健成本.
科学领域:
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
- 流行病学 流行病学
背景情况:
- 呼吸道同胞性病毒 (RSV) 对老年人造成重大健康负担.
- 需要有效的疫苗接种策略来缓解RSV相关的发病率和死亡率.
研究的目的:
- 评估荷兰老年人各种呼吸道同胞病毒 (RSV) 疫苗接种策略的成本效益.
- 确定最佳的疫苗接种计划和目标人群,以最大限度地提高健康结果和经济效益.
主要方法:
- 采用静态决策树成本效益模型,在6个RSV季节中对荷兰成年人进行无接种疫苗与多个RSV疫苗接种策略的比较.
- 策略包括接种60岁以上,75岁以上的个体,以及75岁以上与60-74岁高风险个体的组合,两年和三年间隔.
- 从社会角度评估健康结果和成本,以终身视野,利用最近的发病数据和对疫苗有效性的元分析.
主要成果:
- 每三年接种75岁以上的老人和高风险群体的疫苗被发现是具有成本效益的,平均成本效益比 (ACER) 为30,804欧元/QALY,可以防止大量的GP访问,住院和死亡.
- 最具成本效益的策略是每三年接种≥75岁的人群疫苗 (ICER:23,080欧元/QALY).
- 与≥75和高风险策略相比,每三年接种所有≥60岁的人群的疫苗产生了最高的QALY收益,但具有更高的增量成本效益比率 (ICER).
结论:
- 荷兰老年人接种呼吸道同胞细胞病毒 (RSV) 疫苗是一种经济有效的公共卫生干预措施.
- 针对75岁以上的个体和每三年一次高风险个体的疫苗接种战略代表了资源分配和健康影响的最佳方法.
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