儿童对非尼尼克低奥斯摩拉离子对比介质的急性不良反应:对6年内23,429次注射的回顾性研究
Yewon Seong1, Pyeong Hwa Kim2, Chong Hyun Suh3
1University of Ulsan College of Medicine, Seoul, Republic of Korea.
Korean journal of radiology
|September 28, 2025
概括
在0.89%的儿科病例中,发生了对非离子低度离子对比剂 (LOCM) 的急性不良药反应 (ADR). 高龄和先前反应史是接受LOCM的儿童副作用的关键风险因素.
科学领域:
- 儿科放射学 儿科放射学
- 药物监督 药物监督 药物监督
- 医疗成像安全 医疗成像安全
背景情况:
- 对于含有的对比剂的药物不良反应 (ADR) 可能发生在儿科患者身上.
- 通常使用的是无离子低度对比介质 (LOCM),因此需要了解它们在儿童中的安全性.
研究的目的:
- 确定儿科患者中非离子LOCM急性ADR的发生率.
- 在儿科人口中识别与这些ADR相关的危险因素.
主要方法:
- 从2016年1月到2023年6月,对23429名非离子LOCM注射在儿科患者 (≤18岁) 的回顾性分析.
- 评估每次检查的急性生理和过敏类ADR的发生率和严重程度.
- 多变量波松回归与一般化的估计方程来识别风险因素.
主要成果:
- 在0.89%的儿科LOCM注射中发生了急性过敏类反应,0.55%的儿科LOCM注射发生了生理反应,大多是轻微的.
- 高龄和先前的副作用史是这两种反应类型的显著风险因素.
- 与门诊患者相比,住院/急诊机构的过敏类反应率较低.
结论:
- 非慢性LOCM不良反应在儿科患者中不常见,但与特定的风险因素有关.
- 较年长的儿童和有过反应的儿童需要在增强对比度的过程中保持高度警.
- 这些发现支持针对高风险儿科患者群体进行对比度增强成像的有针对性的安全措施.
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