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开发一个功能性的非动物中枢神经系统应激模型,利用人类iPSC皮层神经元的长期增强,以评估治疗方法

Kaveena Autar¹, Xiufang Guo², Haley Powell²

¹Hesperos, Inc., 12501 Research Parkway, Suite 100, Orlando, FL 32826, USA.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|September 28, 2025

概括

这项研究引入了一个人体器官芯片模型来评估皮质醇.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
生物技术是生物技术.

背景情况:

皮质醇是主要的压力激素,对认知功能产生负面影响.
现有的压力体外模型是有限的.
长期增强 (LTP) 是学习和记忆的关键指标.

研究的目的:

建立一个人体iPSC-皮层神经元器官在芯片上 (HoaC) 模型,用于神经应激.
研究皮质醇对突触功能和认知的影响.
为了评估治疗化合物减轻压力诱导的认知衰退.

主要方法:

使用了人类iPSC-皮层神经元器官在芯片上 (HoaC) 系统.
将神经元暴露在皮质醇中以诱导压力表型.
评估了LTP,突触完整性,形态和电生理学的变化.
测试了紫 Echinacea 和它的活性化合物 dodeca 的治疗效果.

主要成果:

在HoaC系统中暴露于皮质醇诱导了压力表型,改变了LTP,突触完整性和电生理学.
紫和十二显著缓解了皮质醇诱导的压力.
在治疗紫 Echinacea 和 dodeca 时,观察到依赖时间的 LTP 救援.

结论:

人类iPSC-皮层神经元HoaC系统有效地模拟神经应激.
这种模型可以识别应激诱导的认知缺陷的治疗化合物.
紫和多德卡显示出减轻与压力相关的神经功能障碍的潜力.

关键词:

皮层神经元的神经元皮质醇是一种皮质醇.紫色草 (Echinacea purpurea) 是一种紫色的植物.人在芯片上的人类长期增强潜力长期增强潜力微电极阵列是一个微电极阵列.压力压力压力压力

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