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Updated: Jan 16, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

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基因与改变表达的5-Aza治疗通过甲基化在intron1中的骨髓性白血病细胞中的基因表达

Machiko Fujioka1, Hiroyuki Mishima2, Hidehiro Itonaga3

  • 1Department of Hematology, Sasebo City General Hospital, 9-3 Hirase, Sasebo, Nagasaki 857-8511, Japan; Department of Hematology, Life Sciences and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.

Leukemia research
|September 28, 2025
PubMed
概括

5-阿扎丁 (5-Aza) 通过改变基因表达和DNA脱甲基化,有效地治疗髓性白血病. 这项研究确定了关键基因,包括HDC和MICALL2,与患者存活相关,这表明了新的治疗点.

关键词:
亚扎西蒂丁是一种阿扎西蒂丁.通过DNA甲基化.引入 1 引入 1 引入长时间阅读序列.骨髓性白血病 (Myeloid Leukemia) 是一种神经性白血病.

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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells09:16

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