表面电荷转移混合细胞,以克服肠道药物输送障碍
Annika Postina1, Dennis To1, Katrin Zöller1
1Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens-University of Innsbruck, Innrain 80/82, Innsbruck 6020, Austria.
Colloids and surfaces. B, Biointerfaces
|September 28, 2025
概括
这项研究开发了用于增强口服药物输送的新型混合. 这些菌根有效地透粘液并改善细胞吸收,对药物递送系统显示有希望.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 制药科学 制药科学
背景情况:
- 开发有效的口服药物输送系统是具有挑战性的,因为粘液等生物障碍.
- 菌根提供了药物递送的潜力,但需要优化以提高透和细胞吸收.
研究的目的:
- 开发和表征具有协同性能的混合菌根,以改善粘液透和细胞吸收.
- 评估性酸酶 (ALP) 在触发增强细胞吸收中的作用.
主要方法:
- 使用C12-15酒精3乙氧化乙烯 (PME) 和1,2-二oleoyloxy-3-trimethylammonium-propane化物 (DOTAP) 在不同比例中配制米塞尔.
- 评估了光二甲酸盐 (FDL) 的物理化学性质,毒性,粘液透,ALP介导的酸盐释放和细胞吸收.
主要成果:
- 所有发育的菌体都表现出显著的粘液透能力,透能力提高了18倍.
- 混合微粒在ALP介导的酸盐裂变时显示出明显的泽塔电位转移,增强了膜相互作用.
- 这导致模型化合物FDL.的细胞吸收率提高了7到10倍.
结论:
- PME-DOTAP混合菌体表现出高效的粘液透和由酶触发的细胞吸收增强.
- 这些发现突显了PME-DOTAP混合片作为先进的口服输送系统的潜力.
- 协同作用的特性为克服口服药物输送中的生物障碍提供了一个有希望的策略.
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