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超级增强器驱动的ELOVL5通过MYC-SERBP1路径促进T-ALL的进展

Shuqi Zhang1, Wei Cheng1, Tiandan Li2

  • 1Institute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou City 215003, Jiangsu, China; Department of Pediatrics, The First Affiliated Hospital of Wannan Medical College, Wuhu City 241001, China.

Genomics
|September 28, 2025
PubMed
概括

我们发现ELOVL5,一种由超级增强剂调节的基因,是T细胞急性淋巴细胞白血病 (T-ALL) 的关键驱动因素. 沉默ELOVL5可以阻止T-ALL的进展,并改善存活率,将其确定为潜在的治疗标.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.一千五百一十五年我的世界 MYC核武器的扩散在SERBP1中,所有的T-ALL.

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