饮食中含有DHA的脂载体不会增加大脑的DHA水平:一项复制研究
Brinley J Klievik1, Yan Fu1, Aidan D Tyrrell1
1Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Journal of lipid research
|September 28, 2025
概括
食中含有的脂形式的多可萨赫萨酸 (DHA) 并没有增加小鼠的大脑DHA水平. 补充剂证实了全身吸收,但未能复制以前发现的大脑DHA度增加的结果.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 营养科学 营养科学
背景情况:
- 多可萨赫萨酸 (DHA) 对于大脑健康至关重要,主要来自鱼类.
- 脂 (PL) 形式的DHA,如 lysophosphatidylcholine-DHA (LPC-DHA) 和脂胆-DHA (PC-DHA),以前被认为可以显著提高大脑的DHA.
- 相互矛盾的研究结果需要进一步调查PL-DHA形式的疗效.
研究的目的:
- 复制先前关于口服酸盐胆-DHA (PC-DHA) 和酸盐胆-DHA (LPC-DHA) 对大脑DHA水平的影响的发现.
- 为了比较不同饮食形式的DHA (非化的,LPC-DHA,PC-DHA) 在提高大脑DHA度方面的疗效.
- 解决文献中关于PL形式的DHA生物可用性的不一致性.
主要方法:
- 在30天内,每天给小鼠提供含有非化DHA,sn-1 LPC-DHA或di-DHA-PC的玉米油.
- 一个对照组仅接受了玉米油.
- 在各种大脑区域和血中量化了DHA水平 (相对百分比和度),使用气色谱-火焰电离检测.
主要成果:
- 在包括对照组在内的任何治疗组中都没有观察到大脑DHA相对百分比或度的显著差异.
- 与对照组相比,所有补充DHA的组都显示了显著升高的血DHA水平,证实了系统吸收.
- 作为sn-1 LPC-DHA或di-DHA-PC提供的食DHA与非化DHA或对照相比没有增加大脑DHA水平.
结论:
- lysophosphatidylcholine (LPC) 和phosphatidylcholine (PC) 形式的DHA口服不提高小鼠的大脑DHA水平.
- 这项研究未能复制先前的报告,表明从PL-DHA形式中增强大脑DHA吸收.
- 由于这些特定的脂配方,DHA的系统吸收不一定会导致大脑DHA度的增加.
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