利用癌症中的代谢脆弱性:从机制到治疗机会
Zeng-Rong Xue1, Yuan-Yuan Xin1, Wei-Lin Jin1
1Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, PR China.
Cancer letters
|September 28, 2025
概括
癌细胞重编程新陈代谢以求生存,创造脆弱性. 本次审查引入了一个针对癌症的框架.
科学领域:
- 在瘤学瘤学.
- 代谢途径 代谢途径
- 癌症生物学 癌症生物学
背景情况:
- 癌细胞表现出代谢重编程以适应瘤微环境 (TME) 并抵抗治疗.
- 这种调整揭示了特定的代谢漏洞,可用于癌症治疗.
研究的目的:
- 提出一个统一的"机制-战略-翻译"框架,以了解和针对癌症的代谢脆弱性.
- 阐明代谢不灵活性和合成致死性在瘤进展中的作用.
- 审查关键的代谢途径,表观遗传调节,应激防御机制和TME在癌症中的交叉通话.
主要方法:
- 审查有关癌症代谢的现有文献,重点关注核心机制和漏洞.
- 分析新陈代谢途径,表观遗传修饰 (如乳糖化) 和应激反应系统 (自,氧化还原平衡,铁,杯).
- 检查TME内的神经,免疫和代谢成分之间的相互作用,包括微生物群.
主要成果:
- 确定了代谢不灵活性和合成致死性作为癌症代谢脆弱性的关键驱动因素.
- 详细介绍了葡萄糖代谢,乳糖化,自,氧化还原平衡,抗铁和质对瘤进展的贡献.
- 突出了TME中的三方交叉和微生物群在调节瘤发生中的作用.
结论:
- "机制-战略-翻译"框架为了解癌症代谢脆弱性提供了一种新的方法.
- 新兴的目标和策略,包括组合疗法和饮食干预措施,显示出临床翻译潜力.
- 多学科方法和人工智能驱动的多学科分析对于克服代谢异质性和推进癌症治疗等挑战至关重要.
更多相关视频
08:46Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
11.1K
07:48Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
Published on: December 26, 2016
11.8K
相关概念视频
02:53Adaptive Mechanisms in Cancer Cells
7.0K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.0K
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
02:50Combination Therapies and Personalized Medicine
5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K
02:56Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
02:18Cancer
53.5K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.5K