相关实验视频

Updated: Jan 16, 2026

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

长非编码RNA作为口腔状细胞癌的潜在诊断生物标志物:系统性审查和元分析

Xingyu Liu¹, Jing Qiao¹, Han Qin¹

¹Department of Stomatology, Lianyungang Clinical College of Nanjing Medical University, Lianyungang City 222002, Jiangsu Province, China.

Journal of stomatology, oral and maxillofacial surgery

|September 28, 2025

概括

长非编码RNAs (lncRNAs) 在诊断口腔状细胞癌 (OSCC) 中具有很高的准确性. 体液中的lncRNAs是早期OSCC检测的更有效的生物标志物,而不是组织中的生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

口腔状细胞癌 (OSCC) 是一种普遍存在的恶性瘤.
早期发现OSCC对于改善患者的治疗结果至关重要.
需要新的生物标志物来进行准确和及时的诊断.

研究的目的:

评估长非编码RNAs (lncRNAs) 的诊断准确性,用于OSCC.
探索lncRNAs作为生物标记物的潜力,用于早期OSCC检测.

主要方法:

在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行了系统的文献搜索,直到2024年12月.
包括的研究重点是OSCC中lncRNAs的诊断准确性.
使用元分析来汇集诊断指标,如灵敏度,特异性和诊断几率比率 (DOR).

主要成果:

分析了8项涉及532名OSCC患者和446名对照者的研究.
在OSCC诊断中对lncRNAs的聚合灵敏度和特异性为0.87.
在血液和/或唾液中检测到的lncRNAs与基于组织的lncRNAs (DOR:6.24) 相比,显示出显著更高的诊断价值 (DOR:123.22).

结论:

长非编码RNA对口腔状细胞癌具有很高的诊断准确性.
与基于组织的标记物相比,体液中的LncRNA是OSCC检测的优越生物标记物.
对于早期发现和诊断OSCC,LncRNA具有显著的前景.

关键词:

诊断生物标志物诊断生物标志物长的非编码RNA是什么?进行元分析分析.口腔状细胞癌的癌症.

更多相关视频

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Non-LTR Retrotransposons

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...